Preparation of iron oxide nanoparticles for gene therapy application
Gene therapy is the insertion of genetic materials (DNA) into biological cells with the aim of supplementing a defective or mutated gene with a functional one. For gene therapy to be effective, the therapeutic gene must first be delivered to the cell in such a way that is safe, fast and at a sufficient level.
The aim of this work is to evaluate the potential of magnetic iron oxide nanoparticles, prepared from different synthesis techniques, as non-viral vectors in gene therapy. The long term stability in different fluids (e.g. saline and serum) and flow conditions, and biocompatibility of the nanoparticles were also evaluated.
