Preparation and functionalisation of magnetic gold nanoparticles for biosensor applications
Work on this collaborative project with the Gooding group from the School of Chemistry, UNSW, focuses on developing a robust method for the synthesis of tailored composite nanoparticles consisting of a magnetic iron-oxide core and a shell of gold. These composite particles possess the desirable magnetic character of the magnetite core and allow for predictable functionalisation of the gold shell. Such properties make the particles highly suited for potential use in protein separation, targeted drug delivery and biological monitoring. A major aim of this project is to develop a simple and versatile method to produce particles with well-controlled properties and to test these particles in a range of applications.
Major achievements and research highlights
A novel process for the synthesis of gold-shell magnetite-core particles with the requisite properties for use in biomedical applications was successfully developed. The step-wise procedure produces 80 – 100 nm gold coated magnetite particles which can then be functionalised further depending on the intended application.
The successful development of this synthesis method has shifted the focus of the project from particle synthesis to testing of particles for various applications.
Future plans and directions
Modification of the synthesised particles to suit various applications will be studied along with rigorous proof-of-concept testing of the composite nanoparticles and detailed characterisation of the particle properties and behaviour applied to various applications.
Testing of the synthesis method to determine if it can be extended to a range of other substrates and metallic shells which could have applicability in other fields such as catalysis.
Collaborations
Collaborator |
Organisation |
Mr Leo Lai |
School of Chemistry, UNSW |
Prof Justin Gooding |
School of Chemistry, UWA |
